“The Powerpuff Girls” have grown up … and their sugar, spice and everything nice no longer comes in cartoon form.

The 3 leads of the upcoming live-action series — Chloe Bennet, Dove Cameron, and Yana Perrault — were filming the pilot Wednesday in Atlanta … along with former “Scrubs” star, Donald Faison, who plays their creator/father, Professor Utonium.

It’s the first look at the ‘PPG’ stars in their full, colorful costumes … with Bennet in pink playing Blossom, Cameron in blue as Bubbles, and Perrault in the green playing Buttercup.